Anti-aging protein
In China, the aging of the population is becoming more and more serious. Up to now, China has over 230 million people over the age of 60, the only country in the world with over 200 million elderly people. China is aging at the fastest rate in history, and by 2027 it will have transformed from an "aging" society to an "old" one. Recently, researchers in the Department of Development and Stem Cell Biology of the Pasteur Institute have identified key proteins related to aging and clarified the mechanism of aging, which may help to delay the aging process in humans.
Aging refers to the process in which cells are damaged by various types of stress, thereby affecting their proliferation. The accumulation of senescent cells in tissues may lead to organodegeneration and age-related diseases. Studies in animal models have shown that the clearance of these cells can be accompanied by a delay in the rate of aging and a longer healthy period.
Scientists at the Institut Pasteur and CNRS have shown that the gradual depletion of proteinl causes proliferating cells to enter an irreversible aging. In addition, this depletion occurs early and is therefore a determinant of cellular aging. This factor, called CSB, is associated with Cockayne syndrome. Lack of CSB protein or its dysfunction can lead to early aging, photosensitivity, progressive neurological disease and mental retardation in patients with Cockayne syndrome. "We have previously shown that lack or damage to CSB is also a cause of abnormal cell-powered mitochondrial function." "This new study reveals similar changes in the cellular aging process, which is closely related to physiological aging," said Dr. Ricchetti of the Pasteur Institute.
CSB depletion is driven by epigenetic modifications (reversible and regulatory modifications of gene expression without changing the DNA) that block its expression at the DNA level. In addition, the molecules previously identified by researchers that can reverse cell defects in patients with Cockayne syndrome can also reduce the aging process of normal cells. Dr Ricchetti concluded: "these studies suggest an important link between accelerated ageing and normal ageing, and suggest that CSB proteins are a key factor in the resistance to cellular ageing."
Aging refers to the process in which cells are damaged by various types of stress, thereby affecting their proliferation. The accumulation of senescent cells in tissues may lead to organodegeneration and age-related diseases. Studies in animal models have shown that the clearance of these cells can be accompanied by a delay in the rate of aging and a longer healthy period.
Scientists at the Institut Pasteur and CNRS have shown that the gradual depletion of proteinl causes proliferating cells to enter an irreversible aging. In addition, this depletion occurs early and is therefore a determinant of cellular aging. This factor, called CSB, is associated with Cockayne syndrome. Lack of CSB protein or its dysfunction can lead to early aging, photosensitivity, progressive neurological disease and mental retardation in patients with Cockayne syndrome. "We have previously shown that lack or damage to CSB is also a cause of abnormal cell-powered mitochondrial function." "This new study reveals similar changes in the cellular aging process, which is closely related to physiological aging," said Dr. Ricchetti of the Pasteur Institute.
CSB depletion is driven by epigenetic modifications (reversible and regulatory modifications of gene expression without changing the DNA) that block its expression at the DNA level. In addition, the molecules previously identified by researchers that can reverse cell defects in patients with Cockayne syndrome can also reduce the aging process of normal cells. Dr Ricchetti concluded: "these studies suggest an important link between accelerated ageing and normal ageing, and suggest that CSB proteins are a key factor in the resistance to cellular ageing."
